My wife runs a Dodge van that is a flex fuel vehicle…its our second one. There is a reduction in mileage, although it was in the 15-20 percent range. Where I’m at it’s about 50 cents a gallon cheaper, plus it burns cleaner. Most of the ethanol is produced by Minnesota farmers, so it’s worth it to me to support a local enterprise and economy. If you start out with a new vehicle, you’ll have no problems. Ethanol acts as a detergent, so it will clean out gunk from the tank and fuel lines, but to me it’s a good deal.