You really need to experiment with different manufactures, different bullet types, and ultimately different charges (covered by using different manufactures).Every firearm is different in the boring of the chamber, barrel, ect.
All ammunition in factory loads are produced for an over all length specification to that caliber. That way they can fit into the magazine, clip,.. They do vary by bullet weight, bullet syle, and charge. Your rifle’s lands (where the bullet exits the chamber and meets the rifling of the barrel) could easily be 5,10, 20 thousands deeper or shallower than the next rifle you pick up. The difference in the charge, which partially relates to bullet speed and pressure makes up for some of this.
By a bullet traveling slower or faster it “jumps” that gap and shooting a variety of ammo will show you what it likes the best.
Another factor that is under talked about is the barrels twist rate. when looking at the different gr bullets, understand each bullet can/will fly differently based on the rotation (twist) and speed.
As a generic recommendation, I would start in the middle of the range of bullet weights that are available for a 243. Then I would try different manufactures of the same weight. Keep track of how each one patterns. A little trial and error and you’ll hit the magical load that works best in your rifle