A lot of variables here. From what I am reading and what I already know I have a pretty strong feeling if I get a chance on a wolf it will be between 100 and 400+ yards.
Justin, I would suggest you find a nice big rock outcropping overlooking a swamp, blowbown or clear cut and call. I love the country you are talking about but the odds of seeing a wolf in that thick cover is slim.
I agree with Randy guys. Smaller calibers are more than sufficient. A big male wolf will weigh in at 150#. Shooting the bigger calibers is OK but I would make sure you are shooting the right bullet. I have never shot the Bearclaw out of a .30 caliber rifle but we did load it in the .284 (7mm STW) and pushed it along at 3400 ft/sec and we never could get it to expand or slow down. At 100 yards we pushed the bullet throuh three 5 gallon buckets (full of water) and our mock deer chest cavity. Of course experience is worth its weight in gold.
I may load the .280 for this job (just cause I like it so much). However I think the .243 is the right gun for the job……..AND it currently has a 0 body count. The .243 needs to draw blood.