Most guys that time of year live bait rig sucker minnows. There is no doubt that it will probably work the very best for catching the most and biggest fish.
If you’re wanting to catch them on artificial presentations, football jigs rigged with a craw or creature bait works pretty good. Drop shots with a senko or type of plastic worm / leech can be pretty deadly.
Love the river in the fall. We do well using some smaller musky baits Mini Hearthrob or larger tube jigs have done great for us. Put a lot of fish in the boat. Found when they eat they liked them bigger September October time for us.
When in GB live bait will out fish any artificial 4 to 1 in the fall. Also average bigger fish.
Have tried tubes, craws, senkos, swim baits, cranks, etc.
At 45 to 55 degree water those fish want meat if possible.
At least where I find them.