When it comes to predator hunting, you need to first be honest about your walking distance to stand, shot distance, and the animal you’re hunting. Are you concerned with simply putting lead on body, or do you plan on maximizing caliber/bullet for least amount of hide damage? What shot distances do the properties you hunt actually allow? are the yotes pressured and prone to hanging up? How far can you practice shooting? Here in SD, It’s nothing to take a 400 yard shot if a dog hangs up.
Personally, I don’t hunt for fur anymore, and maybe hunt 1 tournament a year, so I just shoot which ever gun feels like the one to take that day. Might be anything from an 11.5″ AR, a shotgun, or my 6.5cm or .270 depending on the style of hunting. I’ve sold off my dedicated predator bolt guns. Select the wrong bullet for a .22-250 and you can peel half the hide off on a runner inside 300 yards, so why not just shoot them with a 143gr ELDX out of the 6.5 then? Don’t need a .223 bolt gun when I’ve got two ARs that provide the same accuracy in the same caliber.
I’ve shot fox and yotes with 9mm, .410, 20 gauge, 16 gauge, 12 gauge, .22lr, .17hmr, .220 swift, .223, .224 valk, .22-250, .243, .243 wssm, 6.5cm, .270, 7.62×39, & .303 british. I’ve had great and marginal hits with all of them, and you’ll see odd things happen if you shoot enough regardless of the caliber, from a DRT shot to the neck with a .22 lr CCI stinger at 100 yards, to a dog that runs 200 yards after getting center punched with a .270 at 250 yards.
The guys I occasionally hunt with in MN are all shooting .224 Valk. They sold somewhere between 80-100 yotes to fur buyers last winter, and left lay probably another 20-340 with mange.