My first screws to come loose were the ones holding the consoles to the gunwale, both port and starboard. I took them all out one at a time and re-inserted using blue loctite. They have not come back out since. This was around opener during my 2nd year of ownership, 2019.
The screws in my floorboards sometimes start to walk up a little bit. Always the ones near the coffin rod storage and the panel in the center that covers the fuel tank. Those ones I haven’t done anything other than re-tighten occasionally. I was afraid to strip them since they’re in wood. I will try out the toothpick method next time!
The floor screws aren’t grabbing in wood. They are going *through* the wood flooring, and grabbing into aluminum ribs that are part of the structure that the wood floor sits on. So still, you don’t want to strip them as that part is relatively thin, but as I noted above, the loctite isn’t likely the best option as the screw is just into “sheetmetal”. In that case, coating it with silicone or 4200 will stop it from turning back out as it will “stick” in the 5/8″ thick plywood too and prevent it from turning.