No, I don’t Joel. I use the white product and haven’t had any apparent fish shying incidents. Really, the 3 pound is like a hair. One does have to take specific care to clean all of the paint from the entire lure eye. Paint is the only issue I have ever really had to deal with and most of the time if I break off its because the eye wasn’t completely cleaned.
As for knots and Nano, the stuff is super slick and knots can be testy. I run the line thru the eye, then tie a slip knot in the end of the line and knot it twice. Then I pass the lure thru the loop and pull out the slack. Works great, ties fast and the Nano has never slipped on me using it.