Depends on the lake and the fishes mood.
Aggressive/Neutral fish on a lake with good average size fish I like a 1/16oz buckshot or rattling flyer. I like to load a spoon with spikes or a minnow head. I let the fish tell me which to use.
Aggressive/Neutral fish on a lake with big perch, but lots of smaller ones to sort through/avoid I like a #3 chubby darter. I like to fish it bare, but if I have to I put 6 to 9 spikes on the front hook.
Negative fish I usually just go to a small northland mud bug or hexi fly loaded with spikes.