Having shot and reloaded a fair bit for handguns and hunted with handguns for over a decade now, I can tell you that the ballistics of the big auto cartridges are laughably bad when compared to long case revolver chambering. I know everybody’s gaga over the 10 MM now, but IMO the 10 MM just makes a marginal improvement on bad.
A 44 magnum drives 180 to 200-grain bullets at roughly 15-1700 FPS. A 10 MM auto drives the same bullet weights at only 900-1100 fps.
Look at what people like guides carry in serious-serious bear country. It is almost exclusively revolvers in the 44 and up class. Bullet choice is also much better in the revolver cartridges.
The only way to survive a disagreement with a bear when armed with a handgun is going to be maximum penetration. You want a hard bullet that does not deform on impact and you want to drive it as hard and fast and deep as possible so it has a chance at punching through bone and getting to vitals while creating a wound channel.
Auto guns are great for plinking and defense against soft, weak, slow 2-footed predators.