Bought my 2016 in with 55k miles on it. Disabled AFM right away. I still average 18.5 in my daily commute, 19.1 if I really pay attention and make an effort to stay off the gas. Mine has a catch can, e85 equipped and tuned for 91+ or e85. It’s pretty fun for a 5.3L turd.
My Wife’s 2016 Tahoe with the identical drivetrain to my silverado is running 100% bone stock. I don’t like it but she doesn’t want to modify anything so we’ll just wait and see. The Tahoe averages 19.5 – 21 depending if it’s a daily commute or a road trip.
My dad has a 2010 5.3L with 70k on the clock and we recently added the Range Technology AFM disabling device. That’s cheap insurance, I would say if any one of these trucks goes it’s going to be the 2010.
As mentioned above, 2014+ were modified to address oil consumption but I don’t believe they solved collapsing lifters. 2019+ now use Dynamic Fuel Management (DFM) which can change a whole lot more than shutting off 4 cylinders. It can bring you down to 1 I believe, given the correct conditions.