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And never ever again buy Drain-o. It just makes dealing with the problem more difficult once the Draino fails.
I never recommend using a drain cleaner on a fully clogged drain. Draino works 100 times better on TV than it does in real life. If it does not go down the drain you are going to have a bigger mess to deal with. Many plumbers including us charge more to have to deal with this.
If its just hair in the drain they make a plastic tool that you can stick down the drain to quickly grad it. Think it a couple bucks at the hardware store. Every house needs on of these.
If its farther down the drain like said above you can try running a snake down the over flow, threw the trap and on down the line. If you can get the trap off you can snake from there to. I like to try and put a kink or two in the end of the snake to help it scour the sides of the pipe.
When done run plenty of hot water down the line to help additional clean the pipe.
or just call a plumber or drain cleaner.