This is a copy of a reply I made to the LMS-480 thread regarding the same error. Probably the same cause.
I too have the LMS-480 and think it is great. Like most of you here I too had the sonar locking issue and “GPS Module Not Responding” error. I’ll tell you from experience with the error that your unit is most likely FINE. Here is what Lowrance told me to do which worked twice. (I’ve never had to sent unit back). The receiver is on a separate power supply than the unit. The receiver, therefore, does not turn off when the unit is off. Sometimes the receiver needs rebooting. Unfortunately the engineers at Lowrance did not put a button or something on the receiver antennae to do this automatically so you have to remove the power wire for 3 minutes then reconnect it. It is the red wire labeled NMEA-2000 according to them. I located wire, pulled hair out trying to figure out how to unhook it and then get it hooked back up so a case of the smarts hit me and I just unhooked everything from the battery. This fixed it both times. Most likely that is all that you need to do. Other than this mild nuissance the unit is superb and I haven’t had any additional issues with it after patching the software. I am ready next time for the receiver error though. I bought a $4 toggle switch from Wal-Mart and mouted it under the dash for the reciever so rebooting it is now just a flip of a switch.
Good luck