At that point in the season it depends on how many deer I have in the freezer..
Deer management in your area is up to you but you cannot control gene pool. You can always shoot a lesser buck to knock that out of the gene pool. As far as a doe I don’t think it is possible. Survival of the fittest will take over at some point. Cars hit them, coyote/wolf kills, and weather play roles you cannot keep a the doe you want alive because she is the biggest and best mother.
I am not sure that I can judge which doe has the better gene pool or pregnant. Unless they have the chronic!(which i have never seen)
Depending on the size of the herd in your area it can be a real challenge to shoot one. In my area hunting pressure after rifle season sometimes can turn every animal into a ghost.
The choice is yours but I think those are a few factors to think about.