.44 mag does a fine job and ammo is plentiful and relatively inexpensive. The .41mag would also be a great round, but ammo is more difficult to find. I have shot the .454 Casull and hope that I never have to fire it again, too much recoil. Makes your hands numb. The .480 Ruger is a sweetie also, would work fine but ammo is expensive and not so plentiful. I have not fired the .500, but it sounds like more gun than would be needed. The key to deer hunting w/ a pistol is shot placement and using an ammunition specifically engineered for hunting. I started hunting deer with Winchester White box 240gr. soft points, the accuracy and price were great. The problem is I got a .44 dia entrance and a .44 dia exit wound. Hollow points have proved much more effective and efficient. Have fun hand gunnin’. Check out the Winchester Platinum line of ammo, I really like it.