Our work trucks have had 5.3 engines in them.
My personal truck has been a 5.7 hemi and now recently a 5.7 tundra.
A lot more power from the hemi and tundra.
The hemi does decent on fuel economy but the 5.3 does a little better.
Repair wise the tundra has them all beat. 5 years and 100 K miles and not a single repair. Just oil changes and a set of tires as far as maintenance.
Additional info.
From 2012 on I ran a programmer in my hemi pick ups I had.
I shut off the MDS and could not see any noticeable difference in fuel economy compared to when I had it activated.