I used to live in Chamberlain for a few years, and was able to learn it pretty well. Don’t get back to fish it as often as I’d like, but hoping to make an April trip there this year.
For lodging, it depends on your taste and budget. High end hotel (for SD standards), I’d recommend Cedar Shore Resort. Cedar Shore
Low end hotel that caters to outdoorsman, I’d recommend Allen’s Hillside. Allen’s Hillside
For a cabin or a camping feel, I’d recommend American Creek Campground. I often rent one of their 4 cabins when I’m in town. They have a 2-4 beds, fridge, microwave, heat, a/c. Right on the river with a good view, and actually good shore fishing too right in front of the cabin if you want to relax and catch an easy night bight on shore after a day in the boat. Not sure if they will have their water running in the campground yet or not at that time though?
American Creek
Any of the other hotels are fine, but they are more just your average hotel along the interstate.
Some good restaurants in Chamberlain are Charlies (right next to Allen’s if you stay there) and Busted Nut (large portions). Another unique option is to go to the casino in Lower Brule for some Prime Rib.
Not sure if you are wanting to fish Lake Sharpe or Francis Case. From what I’ve found and generally speaking, Francis Case usually has the better bite in April, Sharpe in May and June. Sometime in mid-April, there’s going to be about a week where the walleye fishing is on fire really close to Chamberlain. 2 lines are allowed, so if you time up the bite right, both bottom bouncers and pitching jigs toward the rocks will produce at the same time.
Similar fishing to the Mississippi, but also different. It is the Missouri River, but it’s a little more of a “lake feel” to it than what the Mississippi offers.