Get off the water when (before) lightning bolts are coming down!
If you fish the main channel of the Mississippi, and similar circumstances, keep a sharp knife handy in case you need to cut your anchors and get the heck out of there. I know this should never come up, but barges get off course and you don’t want to be tugging at your anchor on a wingdam if that’s going on…
On that same note, make sure your running lights are working – I don’t fish with them on, but put them on whenever there’s another boat in operation anywhere nearby.
If you hand land your flatheads, be sure to have a good boatside light and make sure you locate the hook BEFORE you put your hand in there!
Hold snapping turtles by the tail and as far away from your body as possible!
Get comfortable life jackets and wear them. This is something I’m terrible about but I’m looking to change this year. I fish too many places with deep water, swirling undertow, and nasty timber in the water. May kid myself that I’m a good swimmer, but those are not swimming conditions!