Damn,
see what that info started
Now I have to go the “WUSS” sight and fess up.
I’m right armed and handed but ripped it up as a young’in in fast pitch and football. So I’m pretty sure my bow is rated 55 -70#’s, but I’m set at 60#
ya, that’s right. And max let off!
I think the let off is still what blows! You’d think it should work in reverse too for the let down after holding for always seems like an eternity.
So all that being said, and RUGER 2506 mentioned energy (I reload high power too) I use the 100 grain head. Realizing they won’t have to same energy as a 125. So to make up for it, SPEED ( with out giving up accuracy). Speed does kill (ask the state patrol) 
So with my rig, I go with the (plus or minus)60# pull, max let off, and 100 grain’ers and out to 30 yards, works great and nearly always complete pass throughs. Not sure what 40 yards would do but where I hunt I don’t get that shot. This last Saturday I stood in my stand watching a 8 or 10 point tending a doe at 40-45 yards. I even took some ‘lousy’ video. But it wasn’t my shot.(would have been with the .44 mag)
Whether a bow, gun, or car/truck, whatever, you have to know your own limits and that of your equipment 
(sorry I rambled) 