I’m far from an expert in this area, but when we first got the cabin we would haul those lp tanks laying down and strapped down BUT we made sure the cap was securely on.
I wouldn’t call it a general rule but those are usually hauled and stored up right
I welded for alot of years using coverage gas. Most wasn’t flammable, but when there full that’s somewhere around 2300 lbs of pressure, caps needed to be on to protect the valve, like propane or you had an aweful powerful missile